… degradation. Notably, by examining a matrix of additional cell-surface E3 ubiquitin ligases and
transmembrane receptors, … for ‘on-demand’ degradation. Furthermore, we offer insights on …

… (ICIs) such as antibodies targeting CTLA-4 (ipilimumab), … Targeted protein degradation
could provide a major expansion in the repertoire of modulating immune checkpoint receptors by …

… antibody against the extracellular domain of the receptor. As … low levels of chimeric E3 ligase
expression (indicated by low … Thus, we next examined whether the targeted degradation of …

… or GPCR (G ProteinCoupled Receptor) or a cell surface … small molecular inhibitors or targeted
by specific antibodies; and 5. … as an E3 ubiquitin ligase to promote rapid degradation of p53…

… targeted degradation of IRS-1 by the CUL7 E3 ligase constitutes a core component of the
mTOR negative-feedback loop. This E3 … antibody, and sources for other antibodies as well as …

… targeted protein degradation are DCAF15, DCAF16, and the arylhydrocarbon receptor (AhR)
E3 ligase… Thus, even though PD-L1 degradation was independent of the UPS, this antibody-…

… E3 ubiquitin ligases have so far been exploited for targeted … such as monoclonal antibodies
and oligonucleotide therapies … receptors, leading to degradation of their respective targets 2,…

… an antibody that recognizes Smurf2 bound to the receptors. … This mechwe report on a
novel ubiquitin ligase we call … TGF receptors and is likely critical to target the TGF receptor for …

… E3 ubiquitin ligase and a target protein, leading to polyubiquitination and degradation of the
… and pomalidomide, which bind a substrate receptor of the E3 ligase cereblon (CRBN) 25 , …

… Final transfer of activated ubiquitin to target proteins is coordinated by the E3 ligase, which
… antibody. The Western blot was probed with anti-HA antibody to detect ubiquitinated species. …